Research Article
Frequency and Prognostic Relevance of FLT3 Mutations in Saudi Acute Myeloid Leukemia Patients
Table 1
Summary of the characteristics of the patients included in the study.
| | Parameter | FLT3-mutated patients () | FLT3 WT patients () |
| | Male : female | 13 : 5 | 34 : 45 | | Median age (years) | 38 | 35 | | Median WBCs count | 65 × 109/L | 12.5 × 109/L | | Median platelets count | 53 × 109/L | 71 × 109/L | | Median hemoglobin | 9.1 g/dL | 10 g/dL | | Median PB blasts | 40% | 8% | | History of AML | | | | De novo AML | 18/94 | 76/94 | | Secondary s-AML | 0/3 | 3/3 | | FLT3 mutation rate and OS | | | | FLT3-ITD | 14/97 (14.43%) | NA | | FLT3-D835 | 4/97 (4.12%) | NA | | Total | 18/97 (18.55%) | NA | | Median OS (months) | 10 | 20 | | Cytogeneticanalysis | | | | Available for FISH | 18 | 56 | | Available for karyotype | 13 | 40 | | t (8; 21) | 1 | 6 | | t (15; 17) | 1 | 3 | | inv 16/t (16; 16) | 1 | 3 | | 11q23/MLL | 1 | 2 | | Non recurrent translocations | 0 | 5 | | +8 | 2 | 5 | | +5 | 1 | 1 | | +13 | 0 | 2 | | +21 | 0 | 1 | | −8 | 0 | 1 | | 5q−/−5
| 0 | 2 | | 7q−/−7 | 0 | 2 | | Complex karyotype | 0 | 2 | | Hyperdiploid | 0 | 2 | | Other aberrations | 0 | 4 |
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WT: wild type; OS: overall survival; FISH: fluorescence in situ hybridization.
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