Research Article
Feasibility Study of the “HemoTypeSC” Test for the Rapid Screening of Sickle Cell Disease in Côte D’Ivoire
Table 5
Analysis of the hemoglobin phenotypes by HemoTypeSC™.
| | Phenotype Hb | Sensitivity (TP/(TP + FN)) | Specificity (TN/(TN + FN)) | PPV (TP/(TP + FP)) | NPV (TN/(TN + FN)) |
| | AA | 201/201 | 100% | 135/135 | 100% | 201/201 | 100% | 135/135 | 100% | | AS | 29/29 | 100% | 307/307 | 100% | 29/31 | 93.5% | 307/307 | 100% | | SS | 72/72 | 100% | 263/263 | 100% | 72/76 | 94.7% | 263/263 | 100% | | SC | 20/20 | 100% | 316/316 | 100% | 20/20 | 100% | 316/316 | 100% | | AC | 7/7 | 100% | 329/329 | 100% | 7/7 | 100% | 329/329 | 100% | | CC | 1/1 | 100% | 335/335 | 100% | 1/1 | 100% | 335/335 | 100% | | SAFA2 | 0/2 | 0% | 334/336 | 99.4% | 0/2 | 0% | 334/336 | 99.4% | | SFA2 | 0/4 | 0% | 332/336 | 98.8% | 0/4 | 0% | 332/336 | 98.8% | | Total | 330/336 | 98.2% | 235/235 | 99.7% | 330/342 | 96.5% | 2351/2357 | 99.7% |
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FP, false-positive; FN, false-negative; TP, true-positive; TN, true-negative; PPV, positive predictive value; NPV, negative predictive value.
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