The Success of Treatment Free Remission in Chronic Myeloid Leukaemia in Clinical Practice: A Single-Centre Retrospective Experience from South Africa

Table 1

Small single-centre studies on treatment-free remission in CML.

Study	Kong et al. WCI [30]	Cerveira et al. POI [31]	McMullan et al. BCC [32]	Benjamini et al. MDAH [33]	Lino et al. YPCH [34]	Jumaa et al. BCOH [35]
No. of pt with CML	206	Not reported	105	Not reported	85	Not reported
No. of pt attempting TFR	25	25	21	35 (8)	21 (4)	18
% of pt qualifying for TFR	12.1%	N/A	20%	16%	5%	N/A
No. of months on TKI	N/A	100		96 [8–136]	68 [22–161]	93
No. of months in DMR	N/A	41		63 [1–106]	44 [16–96]	37
Median follow-up after TFR attempt in months	42 [15–154]	24		16 [2–106]	32 [18–69]	24
% success of TFR	56%	58%		59%	67%	72%
Patients who failed TFR attempt
Median period to restarting TKI in months [range]	2.7 [2.7–24]	5 [4–9]		3.5 [1–32]	5 [1–6]	9 [3–12]
Median period to regaining DMR in months [range]		5 [2–10]		6 [2–18]	3	3

CML: chronic myeloid leukaemia; TFR: treatment-free remission; TKI: tyrosine kinase inhibitor; DMR: deep molecular response; WCI: Winship Cancer Institute; POI: Portuguese Oncology Institute; BCOH: Basra Centre for Oncology and Hematology; BCC: Belfast City Hospital; MDAH: MD Anderson Houston; YPCH: Yamanashi Prefectural Central Hospital; No.: number; pt: patient.