The Success of Treatment Free Remission in Chronic Myeloid Leukaemia in Clinical Practice: A Single-Centre Retrospective Experience from South Africa

Table 5

Factors predicting treatment-free response outcome.

Number	Successful TFR; n = 9	Failed TFR; n = 3	value
Age at diagnosis in years, median [range]^†	50 [29–66]	53 [45–59]	0.60
Total duration on TKI in months^†, median [range]	137 [87–192]	96 [87–97]	0.02
Duration of DMR in months^†, median [range]	99 [83–113]	70 [43–82]	0.16
Sokal score, n (%)			0.50
Low	5 (56)	1 (33)
Intermediate	1 (11)	N/A
High	1 (11)	2 (67)
Indeterminate	2 (22)	N/A
Exposure to IFNα, n (%)			0.90
No	7 (78)	3 (100)
Yes	2 (22)	0 (0)
Withdrawal symptoms, n (%)			0.50
No	3 (33)	2 (67)
Yes	6 (67)	1 (33)

^†Two-sample Wilcoxon rank-sum (Mann–Whitney) test; Fisher’s exact; IQR: interquartile range; MR: deep molecular remission; IFNα: interferon alpha; TKI: tyrosine kinase inhibitor.