Capable of inducing cell cycle arrest in G1 and G2 phases and regulation of activated PAK-2 gene expression (transcription)
Both genes’ promoters have been found variously hypermethylated in CLL cases among different studies; common point of these studies was that hypermethylation of CDKN2A and CDKN2B was mutually exclusive in CLL cases
G1-to-S transition of the cell cycle after DNA damage through p53 gene expression (transcription), NOTCH
Aberrant methylation of the KLF4 promoter was significantly associated with gene expression levels compared to normal samples after B cell activation, KLF4 expression was reported to be downregulated