The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review

<table class="table-group" id="tab15"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Gene names</td><td class="align_center">Related pathway</td><td class="align_center">Findings in CLL</td><td class="align_center">Ref.</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">VHL</td><td class="align_center">Class I MHC-mediated antigen processing and presentation</td><td class="align_center">Methylated promoter status was reported in IGVH-unmutated CLL</td><td class="align_center">[<a href="/journals/ah/2024/1370364/#B14" target="_blank">14</a>, <a href="/journals/ah/2024/1370364/#B144" target="_blank">144</a>]</td></tr><tr><td class="align_left">UBE2R2</td><td class="align_center">Class I MHC-mediated antigen metabolism of proteins</td><td class="align_center">Methylation levels in specific CpG sites independently predicted time to treatment with some of them being located in the gene body</td><td class="align_center">[<a href="/journals/ah/2024/1370364/#B29" target="_blank">29</a>]</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>CLL: chronic lymphocytic leukemia, Ref.: reference, MHC: major histocompatibility complex, VHL: von Hippel–Lindau, UBE2R2: ubiquitin conjugating enzyme E2 R2, IGVH: immunoglobulin variable heavy chain gene.<br/></div></td></tr></table>

<div>Class I MHC-mediated antigen processing.</div>

Advances in Hematology

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Table 15

Table 15: The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review 