Review Article
The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review
Table 17
Angiogenesis/erythropoiesis.
| Gene names | Related pathway | Findings in CLL | Ref. |
| SERPINB5 | TAp63 isoforms transcription angiogenesis | Methylated gene body was described in IGVH-unmutated cases | [26, 149] | THBS1 | Involved in platelet aggregation, angiogenesis, and tumorigenesis gene expression (transcription). Reactive oxygen species signaling. Nitrous oxide signaling | THBS1 promoter methylation was detected in 50% of the samples while in normal samples, gene promoters were mainly unmethylated | [51, 150, 151] | TJP1 | Immune cell transmigration VCAM-1/CD106 signaling gene expression (transcription); MAGuK tumor suppressor pathway | TJP1expression was reduced in patients with hypermethylated promoter regions and hypomethylated body regions | [37, 152] |
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CLL: chronic lymphocytic leukemia, Ref.: reference, SERPINB5: serine protease inhibitor B5, THBS1: thrombospondin-1, TJP1: tight junction protein 1, Tap63: tumor protein P63, VCAM-1: vascular cell adhesion protein 1, CD106: cluster of differentiation 106, MAGuK: membrane-associated guanylate kinases, IGVH: immunoglobulin variable heavy chain gene.
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