Nervous system development, SLIT/ROBO signaling pathways
The expression of ROBO1 was significantly lower compared to healthy control samples; when DNA sequencing of the promoter region was performed, in most CLL samples, a higher level of methylation than the healthy individuals was identified
Signaling by NTRKs nuclear events (kinase and transcription factor activation)
Shortened patient survival is associated with high levels of promoter; methylation ID4 promoter methylation is generally methylated in varying levels in CLL cells; ID4 mRNA and protein expression are both silenced in CLL cells, a phenomenon independent of ID4 promoter methylation status
PTPRO gene promoter was methylated and expression was suppressed compared to normal B cells, with overall expression of PTPRO being lower in CLL lymphocytes than in normal samples