The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review

Table 19

Drug uptake mechanisms and sensitivity.

Gene names	Related pathway	Findings in CLL	Ref.
SLC22A18	Drug sensitivity cellular metabolism and growth	Unmethylated gene body status was reported in IGVH-unmutated samples	[26, 162]
SLCO3A1	Transport of inorganic cations/anions and amino acids/oligopeptides and transport of vitamins, nucleosides, and related molecules, drug uptake mechanisms	Differentially methylated regions of the SLCO3A gene have been associated with survival features in CLL cohorts where the hypermethylated status was linked to inferior post-treatment survival	[66]

CLL: chronic lymphocytic leukemia, Ref.: reference, SLC22A18: solute carrier family 22, member 18, SLCO3A1: solute carrier organic anion transporter family member 3A1, IGVH: immunoglobulin variable heavy chain gene.