| | Gene names | Related pathway | Findings in CLL | Ref. |
| | REPS1 | Vesicle-mediated transport and clathrin-mediated endocytosis | Methylation levels in specific CpG sites independently predicted time to treatment with some of them being located in the gene body | [29] | | ATP9B | Ion channel transport and cardiac conduction | Methylation levels in specific CpG sites independently predicted time to treatment with some of them being located in the gene body | [29] | | GRB2 | Downstream signaling of activated FGFR2 and prolactin signaling | Genome-wide methylation profiling identified GRB2 gene body to be differentially methylated | [130] | | DLEU7 | | Analysis did not detect any specific mutations in DLEU7, but DLEU7 expression was absent in CLL cells; methylation of a CpG island in the promoter region of DLEU7 was identified as a possible explanation for the absence of DLEU7 expression, with the promoter reported to be methylated in most of the CLL samples | [179] | | ADAMTS17 | Metabolism of proteins immune cell transmigration, VCAM-1/CD106 signaling, gene expression (transcription). MAGuK tumor suppressor pathway | ADAMTS17 expression was reduced in patients with hypermethylated promoter regions and hypomethylated body regions | [37, 180] | | KCNG2 | Integration of energy metabolism potassium channels | KCNG2 expression was reported to be reduced in patients with hypermethylated promoter regions and hypomethylated body regions | [37, 181] | | ME3 | Respiratory electron transport ATP synthesis TCA cycle | ME3 expression was reported to be reduced in patients with hypermethylated promoter regions and hypomethylated body regions | [37, 182] |
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CLL: chronic lymphocytic leukemia, Ref.: reference, REPS1: RalA-binding protein-associated Eps domain-containing 1, ATP9B: ATPase phospholipid transporting 9B, GRB2: growth factor receptor-bounding protein 2, DLEU7: deleted in lymphocytic leukemia 7, ADAMTS17: a disintegrin and metalloproteinase with thrombospondin motifs 17, KCNG2: potassium voltage-gated channel modifier subfamily G member 2, ME3: malic enzyme 3, FGFR2: fibroblast growth factor receptor 2, VCAM-1: vascular cell adhesion protein 1, CD106: cluster of differentiation 106, MAGuK: membrane-associated guanylate kinase, ATP: adenosine triphosphate, TCA: tricarboxylic acid.
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