The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review
Table 23
Noncoding RNAs.non
Gene names
Related pathway
Findings in CLL
Ref.
CRNDE
Involved in the expression of genes associated to metabolism and in neoplasms biology inversely regulated by insulin and insulin-like growth factors
CRNDE expression was downregulated and the methylation level of CRNDE promoter was higher compared to normal B cells; after exposure to demethylating agents, an increase of CRNDE expression levels was reported
Overexpression of BM742401 in CLL led to interruption of cellular proliferation and increased apoptosis; in CLL cell lines, BM742401 promoter was methylated in 57.1% of the samples compared to normal controls where the promoter was unmethylated; methylation of BM742401 negatively associated with its expression and 5-aza-2′-deoxycytidine exposure caused promoter demethylation with consequent activation of BM742401 expression; methylation of BM742401 correlated with higher Rai stage among in the subgroup of CLL patients with standard-risk cytogenetic features
Positive expression relationship with nearby GDF7 gene. GDF7 protein is involved in growth, repair, and embryonic development
Gene promoter methylation levels reported to be inversely correlated to gene expression levels and survival analysis demonstrated that hypomethylated gene promoter status of AC012065.7 was associated with an inferior prognosis
