Preparation and Characterization of Sodium Alginate/Chitosan Composite Nanoparticles Loaded with Chondroitin Sulfate

Figure 2

SEM images of SA/chitosan micro/nanoparticles loaded with CS prepared by different process parameters. (a)–(d) The voltage of 16 kV, the stirring rate of 800 rpm, and the weight ratio of SA to CS of 5 : 1 at flow rate of (a) 0.3 mL/h; (b) 0.6 mL/h; (c) 1.0 mL/h; (d) 1.2 mL/h. (e, f) The voltage of 16 kV, flow rate of 0.6 mL/h, and the weight ratio of SA to CS of 5 : 1, with a stirring rate of (e) 600 rpm and (f) 1000 rpm. (g, h) The stirring rate of 800 rpm, flow rate of 0.6 mL/h, and the weight ratio of SA to CS of 5 : 1, with applied voltages of (g) 13 kV and (h) 18 kV. (i, j) The stirring rate of 800 rpm, flow rate of 0.6 mL/h, applied voltages of 16 kV, and the weight ratio of SA to CS of (i) 2 : 1; (j) 1 : 1.