Research Article
In Vitro Evaluation of Native Taro Boloso-I Starch as a Disintegrant in Tablet Formulations
Table 1
Formulations and compression forces of tablets (central composite design).
| | No. | Factor 1 | Factor 2 | | Code | Actual | | | Code | Actual | | | X1 | NTBISC [g (%)] | Granules [g (%)] | Mg stearate [g (%)] | X2 | CF (kN) |
| | F1 | −1 | 17.5 (5) | 330.75 (94.5) | 1.75 (0.5) | −1 | 15 | Factorial design points | | F2 | +1 | 52.5 (15) | 295.75 (84.5) | 1.75 (0.5) | −1 | 15 | | F3 | −1 | 17.5 (5) | 330.75 (94.5) | 1.75 (0.5) | +1 | 25 | | F4 | +1 | 52.5 (15) | 295.75 (84.5) | 1.75 (0.5) | +1 | 25 | | F5 | −1.414 | 10.5 (3) | 337.75 (96.5) | 1.75 (0.5) | 0 | 20 | Axial design points | | F6 | +1.414 | 59.5 (17) | 288.75 (82.5) | 1.75 (0.5) | 0 | 20 | | F7 | 0 | 35.0 (10) | 313.25 (89.5) | 1.75 (0.5) | −1.414 | 13 | | F8 | 0 | 35.0 (10) | 313.25 (89.5) | 1.75 (0.5) | +1.414 | 27 | | F9-13 | 0 | 35.0 (10) | 313.25 (89.5) | 1.75 (0.5) | 0 | 20 | Central points |
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NTBISC: NTBIS concentration; CF: compression force.
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