Global Analysis in Nonobstructive Azoospermic Testis Identifies miRNAs Critical to Spermatogenesis

Table 4

Expression of differentially expressed miRNAs in testicular samples of SCOS patients compared to that of OA individuals.

	miRNA ID	log2FoldChange (case/control)	value		Up-/downregulation	Genome location
1	hsa-miR-449a	-8.95712	8.55-66	1.56-62	Down	Chr5
2	hsa-miR-34c-3p	-5.42921	8.53-30	5.19-27	Down	Chr11
3	hsa-miR-375	-5.76047	4.47-28	1.63-25	Down	Chr2
4	hsa-miR-517b-3p	-9.10218	1.50-26	4.57-24	Down	Chr19
5	hsa-miR-512-3p	-8.37851	1.51-25	3.44-23	Down	Chr19
6	hsa-miR-34c-5p	-5.15346	9.05-24	1.84-21	Down	Chr11
7	hsa-miR-520c-3p	-8.11517	1.25-23	2.29-21	Down	Chr19
8	hsa-miR-516b-5p	-6.93696	2.19-23	3.63-21	Down	Chr19
9	hsa-miR-1323	-7.97416	9.51-23	1.45-20	Down	Chr19
10	hsa-miR-34b-3p	-5.32971	9.42-22	1.23-19	Down	Chr11
11	hsa-miR-7-5p	-4.68621	6.21-21	7.09-19	Down	Chr9
12	hsa-miR-449b-3p	-7.00788	1.09-19	1.16-17	Down	Chr5
13	hsa-miR-519d-3p	-7.51046	1.47-19	1.49-17	Down	Chr19
14	hsa-miR-517-5p	-7.92481	6.45-19	6.20-17	Down	Chr19
15	hsa-miR-182-5p	-4.76507	1.21-17	1.00-15	Down	Chr7
16	hsa-miR-891a-5p	-5.35565	5.57-16	4.42-14	Down	ChrX
17	hsa-miR-34b-5p	-4.84987	8.12-16	6.18-14	Down	Chr11
18	hsa-miR-518b	-6.39722	1.15-15	8.04-14	Down	Chr19
19	hsa-miR-515-3p	-6.46087	1.25-15	8.46-14	Down	Chr19
20	hsa-miR-522-3p	-6.18912	1.41-15	9.19-14	Down	Chr19
21	hsa-miR-3663-5p	-5.72328	1.53-15	9.64-14	Down	Chr10
22	hsa-miR-517a-3p	-5.86253	2.84-15	1.73-13	Down	Chr19
23	hsa-miR-7161-5p	-6.70005	5.67-15	3.34-13	Down	Chr6
24	hsa-miR-449c-5p	-6.24951	1.12-14	6.36-13	Down	Chr5
25	hsa-miR-96-5p	-3.51773	1.48-14	8.20-13	Down	Chr7
26	hsa-miR-516a-5p	-7.06944	2.63-14	1.41-12	Down	Chr19
27	hsa-miR-498	-5.88303	1.48-12	7.70-11	Down	Chr19
28	hsa-miR-522-5p	-6.59192	2.33-12	1.18-10	Down	Chr19
29	hsa-miR-1283	-5.5631	2.46-12	1.21-10	Down	Chr19
30	hsa-miR-1299	-4.89852	3.20-12	1.53-10	Down	Chr9
31	hsa-miR-520a-5p	-6.62105	3.50-12	1.64-10	Down	Chr19
32	hsa-miR-520g-3p	-6.41133	2.16-11	9.88-10	Down	Chr19
33	hsa-miR-1269a	-6.41876	2.85-11	1.27-09	Down	Chr4
34	hsa-miR-520f-3p	-5.94296	3.26-11	1.42-09	Down	Chr19
35	hsa-miR-7154-5p	-6.35628	3.71-11	1.57-09	Down	Chr11
36	hsa-miR-520d-5p	-5.54841	4.33-11	1.79-09	Down	Chr19
37	hsa-miR-3529-3p	-2.86549	5.13-11	2.08-09	Down	Chr15
38	hsa-miR-520b	-5.98042	6.80-11	2.70-09	Down	Chr19
39	hsa-miR-122-3p	-5.83444	1.26-10	4.89-09	Down	Chr18
40	hsa-miR-517c-3p	-6.17555	1.98-10	7.51-09	Down	Chr19
41	hsa-miR-888-5p	-4.62783	2.69-10	1.00-08	Down	ChrX
42	hsa-miR-7161-3p	-6.21697	2.76-10	1.01-08	Down	Chr6
43	hsa-miR-518e-3p	-6.09464	3.98-10	1.43-08	Down	Chr19
44	hsa-miR-183-5p	-3.26591	4.81-10	1.69-08	Down	Chr7
45	hsa-miR-31-5p	-3.61452	8.69-10	2.99-08	Down	Chr9
46	hsa-miR-124-3p	-3.03982	9.42-10	3.13-08	Down	Chr8
47	hsa-miR-519b-5p	-5.69616	9.35-10	3.13-08	Down	Chr19
48	hsa-miR-25-5p	-3.09462	2.03-09	6.62-08	Down	Chr7
49	hsa-miR-122-5p	-4.46093	2.12-09	6.80-08	Down	Chr18
50	hsa-miR-520f-5p	-5.88763	2.37-09	7.45-08	Down	Chr19
51	hsa-miR-524-5p	-5.87427	2.74-09	8.48-08	Down	Chr19
52	hsa-miR-515-5p	-5.41886	3.00-09	9.11-08	Down	Chr19
53	hsa-miR-518c-3p	-5.24506	3.34-09	1.00-07	Down	Chr19
54	hsa-miR-523-3p	-5.85544	4.30-09	1.27-07	Down	Chr19
55	hsa-miR-520h	-5.74672	8.56-09	2.48-07	Down	Chr19
56	hsa-miR-7162-3p	-5.73587	1.38-08	3.94-07	Down	Chr10
57	hsa-miR-891b	-4.21921	1.44-08	4.04-07	Down	ChrX
58	hsa-miR-374c-3p	3.487852	1.94-08	5.38-07	Up	ChrX
59	hsa-miR-27a-3p	-5.62798	2.81-08	7.65-07	Down	Chr19
60	hsa-miR-520d-3p	-5.57633	3.40-08	9.12-07	Down	Chr19
61	hsa-miR-519b-3p	-5.57408	3.60-08	9.53-07	Down	Chr19
62	hsa-miR-526b-5p	-5.51974	4.80-08	1.25-06	Down	Chr19
63	hsa-miR-520c-5p	-5.48718	5.46-08	1.40-06	Down	Chr19
64	hsa-miR-523-5p	-5.54306	7.26-08	1.84-06	Down	Chr19
65	hsa-miR-891a-3p	-4.74652	8.79-08	2.20-06	Down	ChrX
66	hsa-miR-890	-4.23732	1.05-07	2.58-06	Down	ChrX
67	hsa-miR-518a-3p	-5.3572	1.39-07	3.32-06	Down	Chr19
68	hsa-miR-9-3p	-2.49706	1.40-07	3.32-06	Down	Chr1
69	hsa-miR-216b-5p	-5.34256	1.54-07	3.60-06	Down	Chr2
70	hsa-miR-512-5p	-5.32522	1.74-07	4.01-06	Down	Chr19
71	hsa-miR-520a-3p	-5.28657	2.28-07	5.21-06	Down	Chr19
72	hsa-miR-224-5p	-2.37211	2.66-07	5.98-06	Down	ChrX
73	hsa-miR-518f-3p	-5.27129	3.19-07	7.10-06	Down	Chr19
74	hsa-miR-449b-5p	-4.28293	5.69-07	1.25-05	Down	Chr5
75	hsa-miR-519a-5p	-5.251	1.03-06	2.23-05	Down	Chr19
76	hsa-miR-552-5p	-5.05373	1.09-06	2.34-05	Down	Chr1
77	hsa-miR-519c-3p	-5.04066	1.34-06	2.83-05	Down	Chr19
78	hsa-miR-10a-3p	-4.91927	2.64-06	5.46-05	Down	Chr17
79	hsa-miR-138-5p	-2.53821	2.65-06	5.46-05	Down	Chr16
80	hsa-miR-31-3p	-3.10722	2.66-06	5.46-05	Down	Chr9
81	hsa-miR-519a-3p	-4.90331	3.06-06	6.21-05	Down	Chr19
82	hsa-miR-3663-3p	-4.18958	4.91-06	9.84-05	Down	Chr10
83	hsa-miR-139-3p	-2.69096	5.79-06	0.000115	Down	Chr11
84	hsa-miR-935	-2.36926	8.48-06	0.000166	Down	Chr19
85	hsa-miR-20b-3p	-3.63398	1.39-05	0.000271	Down	ChrX
86	hsa-miR-302c-3p	-2.57249	1.45-05	0.000278	Down	Chr4
87	hsa-miR-18b-5p	-2.66115	1.83-05	0.000347	Down	ChrX
88	hsa-miR-106a-5p	-3.00341	2.22-05	0.000413	Down	ChrX
89	hsa-miR-92a-2-5p	-4.50185	2.74-05	0.000505	Down	ChrX
90	hsa-miR-3923	-2.46461	3.83-05	0.000699	Down	Chr3
91	hsa-miR-3180-3p	-2.72251	4.28-05	0.000774	Down	Chr16
92	hsa-miR-619-5p	-2.49174	4.40-05	0.000788	Down	Chr12
93	hsa-miR-181b-5p	-3.40787	5.23-05	0.000926	Down	Chr9
94	hsa-miR-371a-3p	-1.87004	6.39-05	0.001121	Down	Chr19
95	hsa-miR-525-5p	-3.98509	7.77-05	0.00135	Down	Chr19
96	hsa-miR-7159-5p	-4.2429	9.71-05	0.001656	Down	Chr6
97	hsa-miR-885-3p	-4.2429	9.71-05	0.001656	Down	Chr3
98	hsa-miR-3180	-2.54454	0.000124	0.002094	Down	Chr16
99	hsa-miR-10a-5p	-1.79915	0.00022	0.003683	Down	Chr17
100	hsa-miR-766-3p	2.208073	0.000223	0.003698	Up	ChrX
101	hsa-miR-105-5p	-2.88496	0.000231	0.003802	Down	ChrX
102	hsa-miR-5698	-3.71593	0.000345	0.005509	Down	Chr1
103	hsa-miR-205-5p	-3.65805	0.000391	0.006046	Down	Chr1
104	hsa-miR-373-3p	-2.62875	0.000389	0.006046	Down	Chr19
105	hsa-miR-95-3p	-1.51027	0.000391	0.006046	Down	Chr4
106	hsa-miR-1228-3p	3.219571	0.000463	0.007105	Up	Chr12
107	hsa-miR-let-7a-3p	-1.77104	0.000495	0.007533	Down	Chr22
108	hsa-miR-216a-5p	-3.30972	0.00052	0.007847	Down	Chr2
109	hsa-miR-526a	-3.83598	0.00057	0.008526	Down	Chr19
110	hsa-miR-892b	-3.83139	0.000605	0.008977	Down	ChrX
111	hsa-miR-524-3p	-3.60166	0.000611	0.008987	Down	Chr19
112	hsa-miR-518d-5p	-3.81687	0.000616	0.008999	Down	Chr19
113	hsa-miR-1298-5p	-3.55837	0.000649	0.009403	Down	ChrX
114	hsa-miR-940	1.860381	0.000766	0.01101	Up	Chr16
115	hsa-miR-6718-5p	-2.77769	0.000941	0.013423	Down	Chr18
116	hsa-miR-217	-3.71504	0.000957	0.013542	Down	Chr2
117	hsa-miR-139-3p	-1.49141	0.001097	0.015399	Down	Chr11
118	hsa-miR-3591-5p	-3.64572	0.001207	0.016811	Down	Chr18
119	hsa-miR-521	-3.61742	0.00132	0.018256	Down	Chr19
120	hsa-miR-199b-3p	2.152197	0.001346	0.018465	Up	Chr9
121	hsa-miR-527	-3.62189	0.001436	0.019552	Down	Chr19
122	hsa-miR-519d-5p	-3.57545	0.001548	0.02092	Down	Chr19
123	hsa-miR-20b-5p	-1.48311	0.001842	0.024713	Down	ChrX
124	hsa-miR-518a-5p	-3.50258	0.001966	0.026189	Down	Chr19
125	hsa-miR-548ad-5p	-2.61279	0.002084	0.027561	Down	Chr2
126	hsa-miR-125b-1	-1.54534	0.002191	0.028763	Down	Chr11
127	hsa-miR-372-3p	-1.55022	0.002313	0.030151	Down	Chr19
128	hsa-miR-1343-5p	3.178463	0.002607	0.033748	Up	Chr11
129	hsa-miR-1268a	2.390785	0.0027	0.034697	Up	Chr15
130	hsa-miR-302a-3p	-2.19397	0.003068	0.039153	Down	Chr4
131	hsa-miR-892a	-2.80124	0.003278	0.041539	Down	ChrX
132	hsa-miR-1268b	2.381553	0.003613	0.045472	Up	Chr17
133	hsa-miR-4433a-5p	2.533323	0.00378	0.047246	Up	Chr2
134	hsa-miR-3660	-3.29753	0.003885	0.048236	Down	Chr5
135	hsa-miR-187-5p	1.909446	0.003939	0.048566	Up	Chr18
136	hsa-miR-9-5p	-1.29072	0.003965	0.04857	Down	Chr1