Serum from Men with the Severe Form of COVID-19 Impairs the Nitric Oxide Signaling Pathway in Isolated Corpus Cavernosum from Mice: An In Vitro Study

Figure 4

Effects of control (●) and COVID-19 (△) serum on the mRNA expression of NOS3 (a), GUCY1A1 (b), GUCY1B1 (c), PDE5A1 (d), CYBB (e), NOX4 (f), and SOD1 (g) in isolated corpus cavernosum (CC) strips of control mice. Each gene was normalized to β-actin mRNA expression levels, and the values are expressed in arbitrary units (a.u.). Effects of control (●) and COVID-19 (△) serum on the protein expression of sGCα1 (h) and sGCβ1 (i) in isolated corpus cavernosum (CC) strips of control mice. Each gene was normalized to β-actin protein expression levels, and the values are expressed in arbitrary units (a.u.). Data represent . The between the parentheses refer to the number of patients and animals used for each protocol. , control serum vs. COVID-19 serum.

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