Evaluation of the Combination of Recombinant FSH and Antioxidant Therapy on DNA Fragmentation Index (DFI) in Infertile Men

Table 4

Therapeutic schemes of different methods and their effect on sperm parameters.

Treatment method	Medication	Duration (month)	DFI decrease (%)	Total sperm count	Sperm motility	Normal morphology	Reference
Hormone therapy	r-FSH (150 IU, every other day)	3	35.4% [1]; 12% [2]	↑ [1]; ↑ [2]	Total ↑ [1]; Progressive↑[2]	↑ [1]; ↑ [2]	[1] [13]; [2] [14]
	r-FSH (150 IU, daily)	3	24.58%	↓	All ↓	—	[12]
Antioxidant therapy	50 mg vitamin E, 500 mg vitamin C, 100 mg Q10	3	38.9%	—	Total ↑; Progressive ↑	↓	[6]
	N/A	3	28.6%	—	—	—	[8]
	30 mg vitamin C, 5 mg vitamin E, 25 μg selenium, 5 mg zinc	3	0%	↓	Total ↑; Progressive ↓	↑	[7]
Combination therapy	r-FSH  μg  IU vitamin  mg  mg folic acid	2	53.84%	↓	Nonprog ↑; Others ↓	↑	This manuscript

↑: increase; ↓: decrease; significant change.