MTHFRC 677T Gene Polymorphism and Homocysteine in North China Patients with Varicocele

Table 3

Comparison of semen parameters, plasma homocysteine levels, and venous blood gas analysis between different genotypes of MTHFR C677T in the VC group and NC group.

Group	Genotype	Number	Sperm motility (PR + NP) (%)	Sperm density × 10^6 mL^−1	MDA in seminal plasma; (nmol·mL^−1)	Hcy; (mmol·L^−1)	PO2 of spermatic vein (mmHg)
VC (100)	CC	37	41.60 ± 12.15	35.30 ± 18.60	1.13 ± 0.46	8.35 ± 3.17	61.00 ± 3.50
	CT	48	24.50 ± 7.45	28.20 ± 6.90	1.43 ± 0.78	14.79 ± 7.36	43.50 ± 3.50
	TT	15	17.40 ± 6.67	16.45 ± 9.75	3.77 ± 1.47	19.84 ± 6.67	32.00 ± 3.50
P	—	—	<0.001	<0.001	<0.001	<0.001	<0.001
NC (100)	CC	35	45.30 ± 11.57^#	37.55 ± 16.60^#	1.04 ± 0.67^#	8.65 ± 4.65^#	—
	CT	49	49.40 ± 1.47	37.45 ± 16.65	1.21 ± 0.89	9.51 ± 5.77	—
	TT	16	41.34 ± 6.67^$	39.80 ± 14.45^$	1.12 ± 0.54^$	9.68 ± 4.11^$	—
^#P	—	—	0.191	0.591	0.511	0.752	—
^$P	—	—	0.130	0.643	0.677	0.451	—

Note. Values are mean ± standard deviation. indicates the comparison of the TT genotype and CC genotype in the VC group; ^# indicates the comparison of the CC genotype in the VC group and NC group; ^$ indicates the comparison of the TT genotype and CC genotype in the NC group. Abbreviations: CC,cytosine–cytosine; CT, cytosine-thymine; TT, thymine–thymine; MDA, malondialdehyde; Hcy, homocysteine; PO₂, pressure of oxygen.