Hyperuricemia Induces Reproductive Damage in Male Rats through Zinc Homeostasis Imbalance and Oxidative Stress

<div>Testosterone synthesis disorder in testis tissue of hyperuricemia rats. (a) Protein expression views and (b) densitrometric quantification analysis of 3<i>β</i>-HSD, CYP11A1 and StAR. 3<i>β</i>-HSD, 3<i>β</i>-Hydroxysteroid dehydrogenase/isomerase; CYP11A1, cytochrome P45011A1 enzyme; GAPDH, glyceraldehy-3-phosphate dehydrogenase; StAR, steroidogenic acute regulatory protein. <span class="nowrap"><svg height="10.7395pt" id="M11" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 53.0975 10.7395" width="53.0975pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,2.179,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 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Andrologia

fig2

Figure 2

Figure 2: Hyperuricemia Induces Reproductive Damage in Male Rats through Zinc Homeostasis Imbalance and Oxidative Stress 