Hyperuricemia Induces Reproductive Damage in Male Rats through Zinc Homeostasis Imbalance and Oxidative Stress

<div>Imbalance of zinc homeostasis in testis of hyperuricemia rats. (a) Total zinc content in testis tissues. The content of zinc metalloenzyme (b) ALP, (c) LDH and (d) ADH in testis tissues. (e) Zinquin ethyl ester probe staining to test free zinc in testicular tissue (Scale bar: 100 <i>µ</i>m). Transcriptional level of (f) ZIP family and (g) ZnT family genes examined by qPCR assay. (h) Protein expression views and densitrometric quantification analysis of ZnT4 and ZIP7. 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compared with CON group.</div>

Andrologia

fig4

Figure 4

Figure 4: Hyperuricemia Induces Reproductive Damage in Male Rats through Zinc Homeostasis Imbalance and Oxidative Stress 