A Biallelic Mutation in CCDC103 Impairs Sperm Motility due to the Absence of Dynein Arms

Figure 2

TEM analysis of spermatozoa from the patient with the CCDC103 mutation shows the absence of dynein arms. Representative TEM image showing cross-sections of the middle and principal piece of sperm flagella from a fertile control and the patient. The green arrow indicates normal CP in the control and patient. The yellow arrow indicates normal DMTs in the control and patient. The red arrow indicates normal DAs in the control and the absence of DAs in the patient. TEM, transmission electron microscopy; CCDC103, coiled-coil domain-containing 103; DA, dynein arm. CP, central pair of microtubules; DMT, peripheral microtubule doublets. Scale bars = 0.2 µm.