A Biallelic Mutation in CCDC103 Impairs Sperm Motility due to the Absence of Dynein Arms

Table 1

Clinical characteristics of the patient.

Personal information	Semen paraments	Flagellum defects
Age, 26 years; Height/weight, 175 cm/60 kg; Infertility time, 3 years	Volume (mL), 3.25 ± 0.45; Total sperm count (×10^6/time), 181.56 ± 1; Sperm concentration (×10^6/mL), 57 ± 8.2 Progressive motility (%), 0 ± 0; Sperm viability (%), 70 ± 2; Normal sperm morphology (%), 2.35 ± 0.45	Coiled (%), 8–10; Bent (%), 15–20; Absent (%), 1–2.5; Short (%), 4.5 ± 1.5; Irregular caliber (%), 2 ± 0.5; Multiple (%), 6 ± 1

Notes: Semen analysis was performed for three times. Semen paraments and flagellum defects data were presented as mean ± SEM, n = 3. Lower limit of the reference value. Volume (mL): 1.5 (1.4–1.7); Total sperm count (×10⁶/time): 39 (34–46); Sperm concentration (×10⁶/mL): 15 (12–16); Progressive motility (%): 32 (31–34); Sperm viability (%): 58 (55–63); Normal sperm morphology (%): 4 (3–4).