A Study of Dual Function and Expression Pattern of Klf4 between Two Different Processes of Differentiation and Maintenance of Pluripotency in Spermatogonial Stem Cells

Figure 7

STRING functional gene analysis using Cytoscape. (a) PPI network of Klf4 as predicted by STRING and the first 50 genes identified. Network nodes are labeled with gene symbols. Each node represents a protein, and edges indicate protein–protein interactions, with line thickness being indicative of evidence strength for a predicted interaction. Yellow node represents Klf4 (confidence score cutoff >0.40). (b) Using the MCODE Cytoscape plugin, the native network is broken down into subnetworks up to the motif level. Each module subnetwork from the native network represents with MCODE score.

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