TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes

Figure 3

TSH increases adherence of sickle erythrocytes to thrombospondin at lower concentrations (1 and 2 mIU/L) and does not change at higher concentrations (3 and 5 mIU/L). The static adhesion experiment with thrombospondin was performed with TSH concentrations 1, 2, 3, and 5 mIU/L, and control. Reading taken at 540 nm absorbance. N = 4. Results expressed as mean ± SEM. , vs control, with 95% confidence interval in one-way ANOVA and Tukey posttest.