Postprocessing of MRIs Using FreeSurfer in Epilepsy Surgery Patients Provides an Excellent Imaging Marker of Hippocampal Sclerosis but Fails to Separate Subtypes

Figure 1

Overview of excluded and included TLE patients. The flow chart shows the patient inclusion process where excluded patients are marked in red and represent patients that (i) did not have presurgical MRIs available for export, (ii) did not meet the MRI criteria listed in Table 1, (iii) had lesionectomies where the hippocampus was not included in the resection, (iv) MRIs that could not be exported, (v) had clinically significant software segmentation errors in FreeSurfer, (vi) were reoperated before one year postsurgical follow-up, (vii) had bilateral hippocampal pathology, or (viii) had incomplete or fragmented hippocampal tissue samples that were insufficient for histopathological diagnosis or HS ILAE classification. The resulting 92 included TLE patients are presented according to histopathological diagnosis. TLE = temporal lobe epilepsy; MRI = magnetic resonance imaging; HS = hippocampal sclerosis; ILAE = International League Against Epilepsy; FCD = focal cortical dysplasia.