Postprocessing of MRIs Using FreeSurfer in Epilepsy Surgery Patients Provides an Excellent Imaging Marker of Hippocampal Sclerosis but Fails to Separate Subtypes

Figure 3

HS diagnosis by computer-aided method (a) and expert visual assessment (b). (a) The bootstrapped () receiver operator characteristic (ROC) curve for detection of HS based on WH and CA1 volume asymmetry ratios (VARs) in the HS patient group versus the no-HS patient group. For each data point, the brackets represent the bootstrap-generated confidence interval for the curve. The text box lists the area under the curve (AUC) values and the sensitivity, specificity, and VAR values at the optimal threshold of the curve (blue and red circles). (b) The contingency table for HS diagnosis by visual examination performed by neuroradiologists specialized in epilepsy diagnostics. HS = hippocampal sclerosis; WH = whole hippocampus; TP = true positives; FP = false positives; TN = true negatives; FN = false negatives.

(a) HS diagnosis by WH and CA1 VAR

(b) HS diagnosis by visual assessment