Postprocessing of MRIs Using FreeSurfer in Epilepsy Surgery Patients Provides an Excellent Imaging Marker of Hippocampal Sclerosis but Fails to Separate Subtypes

Table 1

Patient MRI inclusion and exclusion criteria. Details on the individual MRI acquisition parameters are available in supplementary information.

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MRI inclusion and exclusion criteria

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Inclusion criteria

 (i) Presurgical 3 T MRIs from Copenhagen University Hospital Hvidovre or Oslo University Hospital Rikshospitalet including the following sequences:

  (a) 3D MPRAGE T1w images with isotropic millimetric voxel resolution

  (b) 2D TSE T2w coronal images with high in-plane submillimetric voxel resolution

Exclusion criteria

 (i) MRI abnormalities hampering successful processing in FreeSurfer, entailing:

  (a) Structural nonepileptogenic lesions (i.e., not presumed to be part of seizure generation or propagation)

  (b) Previous brain surgery

  (c) Marked movement artefacts

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MRI = magnetic resonance imaging; 3 T = 3 Tesla; MPRAGE = magnetization-prepared rapid acquisition gradient echo; T1w = T1-weighted; FSE = fast spin-echo; T2w = T2-weighted.