Acta Neurologica Scandinavica

Research Article

Perampanel Monotherapy for Focal and Generalized Epilepsy in Clinical Practice

Table 1

Demographic and baseline characteristics (full analysis set).
CharacteristicFull analysis set
Gender
 †266
 Female, (%)136 (51.1)
 Male, (%)130 (48.9)
Age
 †204
 Mean (SD) (years)44.0 (21.5)
 Median (range) (years)41.0 (7.0–96.0)
Age category
 †204
 <12 years, (%)3 (1.5)
 ≥12–<18 years, (%)18 (8.8)
 ≥18–64 years, (%)140 (68.6)
 ≥65 years, (%)43 (21.1)
Age at epilepsy onset
 †145
 Mean (SD) (years)30.7 (24.1)
 Median (range) (years)21.0 (0.0–90.0)
Duration of epilepsy
 †145
 Mean (SD) (years)13.2 (13.9)
 Median (range) (years)8.0 (0.1–65.0)
Etiology‡
 †188
 Structural, (%)80 (42.6)
  Vascular, (%)29 (15.4)
  Tumor, (%)18 (9.6)
  Trauma, (%)6 (3.2)
 Genetic, (%)54 (28.7)
 Unknown, (%)50 (26.6)
 Infectious, (%)4 (2.1)
Learning disability
 †132
 Yes, (%)15 (11.4)
 No, (%)117 (88.6)
Psychiatric comorbidity
 †181
 Yes, (%)25 (13.8)
 No, (%)156 (86.2)
Type of psychiatric comorbidity
 †181
 Depression, (%)15 (8.3)
 Anxiety, (%)6 (3.3)
 Mood disorder, (%)3 (1.7)
 Hyperactivity, (%)1 (0.3)
 Obsessive-compulsive disorder, (%)1 (0.3)
 Others, (%)2 (0.6)
Seizure type
 †220
 Focal-onset only, (%)165 (75.0)
 Generalized-onset only, (%)54 (24.5)
 Both focal-onset and generalized-onset, (%)1 (0.5)
Seizure frequency (month)
 Total seizures
  †66
  Mean (SD)1.9 (4.1)
  Median (range)0.8 (0.3–30.0)
 Focal-onset seizures
  †53
  Mean (SD)2.2 (4.6)
  Median (range)1.0 (0.3–30.0)
 Generalized-onset seizures
  †13
  Mean (SD)0.6 (0.4)
  Median (range)0.3 (0.3–1.7)
Number of previous ASMs
 †173
 Mean (SD)2.7 (2.8)
 Median (range)2.0 (0–15)
Number of previous ASMs
 †173
 0, (%)22 (12.7)
 1, (%)55 (31.8)
 2, (%)36 (20.8)
 3, (%)18 (10.4)
 4, (%)9 (5.2)
 5, (%)9 (5.2)
 ≥6, (%)24 (13.9)
Most frequently used§ previous ASMs
 †64
 Levetiracetam, (%)32 (50.0)
 Lamotrigine, (%)15 (23.4)
†Number of PWE for whom datum in question was available; ‡International League Against Epilepsy 2017 classification; §≥20% of PWE. ASM: antiseizure medication; PWE: people with epilepsy; SD: standard deviation.