Association of Lateralized Interictal Epileptiform Discharges with Postsurgical Seizure Outcomes in Patients with Tuberous Sclerosis Complex: A 10-Year Retrospective Study at a Single Center

Table 4

The relationship between IED patterns and clinical characteristics in TSC patients.

IED patterns	Gene variant		Seizure frequency			Number of ASMs				IQ
	TSC1	TSC2	1-3/w	4-10/w	>10/w	1	2	3	4
Focal	2 (22.2)	7 (77.8)	6 (50)	3 (25)	3 (25)^a	2 (16.7)	4 (33.3)	4 (33.3)	2 (16.7)	59.6 (35-71)
Lateralized	4 (17.4)	19 (82.6)	12 (38.7)	15 (48.4)	4 (12.9)^b,c	5 (16.1)	14 (45.2)	9 (29.0)	3 (9.7)	57.1 (39-93)
Multifocal	2 (16.7)	10 (83.3)	2 (14.3)	5 (35.7)	7 (50)	2 (14.3)	5 (35.7)	4 (28.6)	3 (21.4)	56.9 (31-42)
Generalized	3 (15)	17 (85)	2 (8)	7 (28)	16 (64)	1 (4)	10 (40)	8 (32)	6 (24)	57.1 (30-86)

Abbreviations: IEDs: interictal epileptiform discharges; TSC: tuberous sclerosis complex; ASMs: antiseizure medications. Values are (%) or mean (range). ^a, the percentage of seizure frequency in patients with this group versus the data in the generalized group. ^b, the percentage of seizure frequency in patients with this group versus the data in the multifocal group. ^c, the percentage of seizure frequency in patients with this group versus the data in the generalized group.