Research Article
Prognosis and Outcome of Cerebral Sinus Venous Thrombosis—A Multicenter Cohort Study
Table 2
Comparison of CSVT patients, favorable outcome, and unfavorable outcome.
| | Characteristics | Favorable outcome
| Unfavorable outcome
| |
| | Age, mean (SD) | 38.5 (16.3) | 55.0 (20.5) | <0.001 | | Gender, male (%) | 136 (34) | 29 (31) | 0.653 | | Dehydration (%) | 10 (3) | 1 (1) | 0.632 | | Infections (%) | 24 (6) | 6 (7) | 0.684 | | Smoking (%) | 78 (19) | 14 (15) | 0.339 | | Hyperlipidemia (%) | 27 (6) | 21 (23) | <0.001 | | Hypertension (%) | 23 (6) | 24 (26) | <0.001 | | Obesity (%) | 20 (5) | 1 (1) | 0.088 | | Diabetes (%) | 15 (4) | 16 (17) | <0.001 | | Malignancy (%) | 44 (11) | 32 (35) | <0.001 | | Previous thrombotic events (%) | 34 (9) | 6 (7) | 0.525 | | Oral contraceptives (%) | 95 (24) | 10 (11) | 0.006 | | Clinical presentation | | | | | Papilledema (%) | 108 (27) | 17 (19) | 0.141 | | Headache (%) | 325 (82) | 46 (51) | <0.001 | | Vomiting (%) | 71 (18) | 8 (9) | 0.064 | | Seizure (%) | 60 (15) | 38 (41) | <0.001 | | Any focal neurological deficit (%) | 81 (20) | 49 (54) | <0.001 | | NIHSS upon admission, mean (SD) | 0 (0-0) | 2 (0-6) | <0.001 | | Hematological workup | | | | | APLA (%) | 55 (14) | 6 (7) | 0.06 | | Protein C/S deficiency (%) | 17 (4) | 3 (3) | 0.849 | | Factor V deficiency (%) | 32 (8) | 4 (4) | 0.244 | | Factor II mutation (%) | 9 (2) | 0 (0) | 0.153 | | PT 20210 | 18 (5) | 7 (8) | 0.181 | | Behcet’s disease (%) | 18 (5) | 0 (0) | 0.042 | | MTHFR (%) | 20 (5) | 1 (1) | 0.101 | | JAK 2 (%) | 29 (7) | 4 (4) | 0.435 | | Thrombocytosis (%) | 22 (6) | 2 (2) | 0.196 | | Hyperhomocysteinemia (%) | 8 (2) | 0 (0) | 0.181 | | Any coagulopathy (%) | 174 (44) | 18 (20) | <0.001 | | Radiological findings | | | | | Multiple veins (%) | 89 (22) | 35 (38) | 0.002 | | Cortical (%) | 38 (10) | 15 (16) | 0.059 | | Deep (%) | 16 (4) | 7 (8) | 0.141 | | Venous infarction (%) | 25 (6) | 24 (26) | <0.001 | | ICH (%) | 57 (14) | 26 (28) | <0.001 | | Involved sinus (%) | | | | | Superior sagittal sinus (%) | 140 (25) | 46 (51) | 0.008 | | Transverse sinus (%) | 272 (69) | 59 (64) | 0.525 | | Sigmoid sinus (%) | 267 (67) | 54 (59) | 0.124 | | Cavernous sinus (%) | 7 (2) | 3 (3) | 0.357 | | MRS 90 (IQR) | 0 (0-0) | 3 (2-5) | <0.001 |
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NIHSS: National Institute of Health Stroke Scale, APLA: antiphospholipid antibodies, PT 20210: prothrombin 20210, MTHFR: methylenetetrahydrofolate reductase, ICH: intracerebral hemorrhage, SSS: superior sagittal sinus, MRS: modified Rankin scale, IQR: interquartile range.
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