Estimates and Predictors of Mortality, Stroke Recurrence, and Functional Dependency 1-Year after Ischemic Stroke: A Prospective Multicenter Longitudinal Cohort Study in Central Norway
Table 3
Cox age-adjusted and multivariable proportional hazards models for stroke recurrence. In the multivariable models, the total number of available cases in the multivariable analyses was and events .
Characteristic
Age-adjusted
Multivariable model 1
Multivariable model 2
HR1
95% CI2
value
HR1
95% CI2
value
HR1
95% CI2
value
Age (years)
1.01
0.99-1.04
0.30
1.02
0.99-1.05
0.30
1.01
0.98-1.04
0.50
Male
1.52
0.82-2.80
0.20
1.44
0.76-2.73
0.30
1.16
0.61-2.20
0.60
Modified Rankin scale
Dependent 3-4
0.67
0.27-1.65
0.40
0.65
0.25-1.70
0.40
0.60
0.23-1.55
0.30
Stroke etiology
0.80
Small vessel occlusion
—
—
Large artery atherosclerosis
1.70
0.67-4.31
Cardioembolism
1.50
0.59-3.83
Stroke of other determined etiology
1.68
0.51-5.60
Stroke of undetermined etiology
1.61
0.68-3.84
Complications during hospital stay
1.42
0.71-2.83
0.30
Thrombolysis
1.71
0.91-3.21
0.094
NIHSS day 1†
0.99
0.92-1.06
0.70
0.99
0.92-1.06
0.80
0.99
0.93-1.07
0.90
Charlson comorbidity burden
0.064
0.078
0—none
—
—
—
—
1—low
1.36
0.56-3.30
1.24
0.49-3.11
2-3—moderate
2.38
1.11-5.10
2.36
1.08-5.16
4 or more—high
2.65
1.09-6.48
2.58
1.03-6.46
Atrial fibrillation
1.43
0.75-2.74
0.30
1.53
0.78-3.01
0.20
1.40
0.71-2.74
0.30
Antihypertensive
1.29
0.69-2.40
0.40
1.17
0.62-2.24
0.60
1.06
0.56-2.02
0.80
Statin therapy
0.93
0.42-2.05
0.90
0.81
0.35-1.91
0.60
0.86
0.37-1.99
0.70
Diabetes mellitus
1.30
0.64-2.61
0.50
1.40
0.67-2.90
0.40
Current smoker
1.45
0.74-2.86
0.30
CAD§
0.76
0.35-1.64
0.50
0.61
0.27-1.38
0.20
1HR = hazard ratio, 2CI = confidence interval. †National Institutes of Health Stroke Scale (NIHSS). §Coronary artery disease (CAD).
