Estimates and Predictors of Mortality, Stroke Recurrence, and Functional Dependency 1-Year after Ischemic Stroke: A Prospective Multicenter Longitudinal Cohort Study in Central Norway

Table 4

Age-adjusted and multivariable logistic regression models for functional dependence (mRS 3-5). The total number of available cases in the multivariable analyses was and events .

Characteristic	Age-adjusted			Multivariable model 1			Multivariable model 2
	OR^1	95% CI^2	value	OR^1	95% CI^1	value	OR^1	95% CI^2	value
Age (years)	1.12	1.10-1.15	<0.001	1.09	1.05-1.14	<0.001	1.10	1.06-1.15	<0.001
Male	0.75	0.45-1.28	0.30	0.69	0.36-1.30	0.30	0.78	0.42-1.48	0.40
Stroke etiology			0.016
Small vessel occlusion	—	—
Large artery atherosclerosis	2.75	1.19-6.57
Cardioembolism	3.14	1.45-7.14
Stroke of other determined etiology	2.84	0.99-7.89
Stroke of undetermined etiology	1.37	0.58-3.31
Complications during hospital stay	3.57	1.93-6.53	<0.001
Thrombolysis	0.60	0.27-1.19	0.20
NIHSS Day 1^†	1.27	1.18-1.38	<0.001	1.26	1.17-1.38	<0.001	1.29	1.19-1.41	<0.001
Charlson comorbidity burden			0.086						0.055
0—none	—	—					—	—
1—low	2.24	1.15-4.39					2.71	1.25-5.96
2-3—moderate	1.50	0.74-3.02					1.82	0.78, 4.21
4 or more—high	2.14	0.90-4.92					2.57	0.92-6.94
Atrial fibrillation	1.58	0.88-2.77	0.11	1.00	0.48-1.97	>0.90	0.98	0.47-1.94	>0.90
Antihypertensive	1.35	0.78-2.42	0.30	1.39	0.71-2.84	0.30	1.47	0.76-2.96	0.30
Statin therapy	0.64	0.29-1.52	0.30	1.03	0.40-2.95	>0.90	1.01	0.39-2.90	>0.90
Diabetes mellitus	1.56	0.82-2.87	0.20	1.21	0.54-2.61	0.60
Current smoker	1.08	0.50-2.17	0.80
CAD^§	1.87	1.03-3.34	0.036	2.03	0.99-0.4.13	0.052

¹OR = odds ratio; ²CI = confidence interval. ^†National Institutes of Health Stroke Scale (NIHSS). ^§Coronary artery disease (CAD).