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| Studies | Study design | Fusion type | Conc of PLT in PRP | Preparation of PRP | Material used | Sex (m/f) | Follow-up time (months) | Evaluation |
|
| 1. Kubota et al. [15] | Retrospective case series | Lumbar PLF | 8.7 | 400 mL of peripheral blood centrifuged. Buffy coat isolated. The second centrifugation done. 22 mL mixed with calcium chloride. | Local bone, CA, PRP (n = 11)
Local bone CA (n = 9) | 10/10 | 24 | CT |
|
| 2. Kubota et al. [9] | Prospective | Lumbar PLF | 7.7 | 400 mL of peripheral blood centrifuged. Buffy-coat isolated. The second centrifugation done. 22 mL mixed with calcium chloride. | ABG lamina, PRP (n = 25)
ABG lamina (n = 25) | 29/21 | 24 | Radiograph, CT |
|
| 3.Tarantino et al. [10] | Prospective cohort | Lumbar PLF | Not measured | Venous blood centrifuged at 3100 rpm for 8 minutes. Buff coat removed. Platelets were suspended in plasma while shaking the tubes and were ready for use. | Heterologous bone, PRP (n = 20)
Heterologous bone (n = 20) | 8/12 | 6 | CT |
|
| 4. Sys et al. [16] | Prospective | Lumbar IF | Not measured | 54 mL of peripheral blood put in SymphonyTM Platelet Concentration System (DePuy, Johnson & Johnson). | CA, ABG iliac, PRP (n = 19)
CA, ABG iliac (n = 19) | 24/14 | 12 | Radiograph, CT |
|
| 5. Land et al. [17] | Retrospective | Thoracic or lumbar IF | 5 | 16 mL of peripheral blood in REGEN-THT_ (thrombocyte harvesting tube) followed by the addition of Ca gluconate and ethanol. | ABG local bone, PRP (n = 14)
ABG local bone (n = 14) | 9/5 | 6 | Radiograph CT |
|
| 6. Tsai et al. [18] | Prospective | Lumbar PLF | Not measured | 10 mL of FFP mixed with calcium chloride. Mixture shaken for 30 minutes and ready for use. | ABG lamina PRP (n = 33)
ABG lamina (n = 34) | 17/50 | 24 | Radiograph, CT |
|
| 7. Hartmann et al. [11] | Prospective | Lumbar or thoracic PLF | Not measured | 110 mL PVB in Gravitational Platelet Separation (GPS™) System mixed with thrombin. | CA, ABG fracture, PRP (n = 15)
CA, ABG fracture (n = 20) | 23/12 | 8 | CT |
|
| 8. Feiz-Erfan et al. [12] | Prospective | Cervical IF | Not measured | Anticoagulated blood put in Symphony (DePuy, Johnson & Johnson). | Cortical allograft bone, PRP (n = 42)
Cortical allograft bone alone (n = 39) | 21/29 | 24 | Radiograph |
|
| 9. Jenis et al. [14] | Prospective | Lumbar PLF | Not measured | 450 mL PVB in centrifuge. Buffy coat mixed with thrombin. | Allograft bone, PRP(n = 15)
ABG iliac bone (n = 22) | 24/13 | 24 | Radiographic CT |
|
| 10. Carreon et al. [13] | Retrospective cohort study | Lumbar PLF | Not measured | 500 mL PVB, in a centrifuge. A buffy coat mixed with calcium chloride. | ABG iliac, PRP (n = 76)
ABG iliac alone (n = 76) | 40/36 | 24 | Radiographic CT |
|
| 11. Castro et al. [19] | Retrospective | TLIF | 3.5 | 1 unit of PVB in centrifuge. A buffy coat mixed thrombin | AGF, iliac bone (n = 22) iliac bone (n = 62) | 27/57 | 41 | Radiograph |
|
| 12. Hee et al. [20] | Prospective | Lumbar PLF | 4.89 | 450 cc of WB in centrifuge buffy coat mixed with thrombin | CA, ABG iliac (n = 23)
ABG iliac (n = 111) | 50/84 | 24 | Radiograph |
|
| 13. Weiner and Walker [21] | Retrospective | Lumbar PLF | Not measured | From 1 unit of arterial blood, buffy coat collected and put in ultraconcentrator. Thrombin was added and the PRP was ready for use. | ABG iliac PRP(n = 32)
ABG iliac (n = 27) | 24/35 | 12 | Radiograph |
|
| 14. Imagama et al. [2] | Prospective | Lumbar PLF | 7.74 | 400 mL of WB put in centrifuge for 15 minutes, buffy coat collected. Buffy coat put in centrifuge again for 15 minutes followed by the addition of thrombin. | ABG local bone and PRP(n = 29)
ABG local bone (n = 29) | 11/18 | 120 | CT |
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