Determinants of Virologic Failure among Adult HIV Patients on First-Line Antiretroviral Therapy at Waghimra Zone, Northern Ethiopia: A Case-Control Study

Table 3

Medication-related factors on ART clients at Waghimra zone health institution ART clinic, Northern Ethiopia, in 2019 (n = 276).

Variable	Cases (n %)	Control (n %)	Chi-square (X^2)	value
ART regimen at baseline			3.038	0.219
AZT based	58 (63.1)	98 (53.3)
TDF based	21 (22.8)	60 (32.6)
D4T based	13 (14.1)	26 (14.1)
ART regimen at the time of VL testing			3.251	0.071
AZT based	59 (64.1)	97 (52.7)
TDF based	33 (35.9)	87 (47.3)
Duration on ART in years
<5 years	10 (10.9)	50 (27.2)	9.583	0.002
≥5 years	82 (89.1)	134 (72.8)
Drug toxicity
Yes	32 (34.8)	35 (19)	8.288	0.004
No	60 (65.2)	149 (81)	0.567	0.451
ART shift on first-line drugs
Yes	29 (31.5)	50 (27.2)
No	63 (68.5)	134 (72.8)
ART medication adherence
Good	43 (46.7)	155 (84.2)	42.54	0.001
Poor	49 (53.3)	29 (15.8)
CPT use
Yes	72 (78.3)	134 (72.8)	0.957	0.328
No	20 (21.7)	50 (27.2)