Research Article
Clinical and Histopathological Factors Associated with the Tumoral Expression of TGF-β1, MED15, CD16, and CD57 in Oral Squamous Cell Carcinoma
Table 1
The correlation matrix among variables, calculated using the Spearman coefficient.
| | Sex: male | Age | Tumor size | Tumor volume | Tumor depth | Grade | Necrosis | Lymph invasion | Vascular invasion | Perineural invasion | Nodal extension | Stage | Smoking |
| Sex: male | Rho | | −0.035 | 0.165 | −0.013 | −0.112 | 0.109 | 0.216 | 0.110 | −0.040 | 0.025 | 0.038 | 0.182 | 0.334 | | | 0.811 | 0.266 | 0.932 | 0.459 | 0.466 | 0.144 | 0.460 | 0.790 | 0.869 | 0.801 | 0.220 | 0.020 |
| Age at diagnosis | Rho | −0.035 | | 0.166 | 0.147 | 0.062 | −0.249 | −0.023 | 0.157 | 0.215 | 0.123 | −0.212 | −0.038 | −0.019 | | 0.811 | | 0.266 | 0.325 | 0.681 | 0.092 | 0.878 | 0.292 | 0.146 | 0.412 | 0.153 | 0.799 | 0.897 |
| Tumor size (mm) | Rho | 0.165 | 0.166 | | 0.775 | 0.359 | −0.014 | 0.123 | 0.376 | 0.200 | 0.311 | −0.042 | 0.349 | −0.111 | | 0.266 | 0.266 | | <0.001 | 0.014 | 0.928 | 0.409 | 0.009 | 0.177 | 0.033 | 0.780 | 0.016 | 0.459 |
| Tumor volume (ml) | Rho | −0.013 | 0.147 | 0.775 | | 0.653 | −0.170 | 0.077 | 0.173 | 0.116 | 0.387 | −0.083 | 0.305 | −0.234 | | 0.932 | 0.325 | <0.001 | | <0.001 | 0.252 | 0.608 | 0.246 | 0.439 | 0.007 | 0.577 | 0.037 | 0.114 |
| Depth of invasion (mm) | Rho | −0.112 | 0.062 | 0.359 | 0.653 | | 0.033 | 0.110 | 0.155 | 0.114 | 0.224 | 0.028 | 0.091 | −0.167 | | 0.459 | 0.681 | 0.014 | <0.001 | | 0.826 | 0.467 | 0.302 | 0.451 | 0.134 | 0.852 | 0.546 | 0.267 |
| Histology grade | Rho | 0.109 | −0.249 | −0.014 | −0.170 | 0.033 | | 0.108 | 0.108 | 0.012 | −0.110 | 0.348 | 0.336 | 0.109 | | 0.466 | 0.092 | 0.928 | 0.252 | 0.826 | | 0.468 | 0.468 | 0.939 | 0.462 | 0.016 | 0.021 | 0.464 |
| Necrosis presence | Rho | 0.216 | −0.023 | 0.123 | 0.077 | 0.110 | 0.108 | | 0.238 | 0.011 | −0.089 | 0.077 | −0.119 | 0.075 | | 0.144 | 0.878 | 0.409 | 0.608 | 0.467 | 0.468 | | 0.107 | 0.940 | 0.553 | 0.607 | 0.426 | 0.618 |
| Lymphatic invasion | Rho | 0.110 | 0.157 | 0.376 | 0.173 | 0.155 | 0.108 | 0.238 | | 0.672 | 0.125 | 0.077 | 0.053 | −0.217 | | 0.460 | 0.292 | 0.009 | 0.246 | 0.302 | 0.468 | 0.107 | | <0.001 | 0.402 | 0.607 | 0.723 | 0.142 |
| Vascular invasion | Rho | −0.040 | 0.215 | 0.200 | 0.116 | 0.114 | 0.012 | 0.011 | 0.672 | | 0.284 | −0.127 | 0.090 | −0.052 | | 0.790 | 0.146 | 0.177 | 0.439 | 0.451 | 0.939 | 0.940 | <0.001 | | 0.053 | 0.395 | 0.545 | 0.730 |
| Perineural invasion | Rho | 0.025 | 0.123 | 0.311 | 0.387 | 0.224 | −0.110 | −0.089 | 0.125 | 0.284 | | −0.027 | 0.164 | −0.084 | | 0.869 | 0.412 | 0.033 | 0.007 | 0.134 | 0.462 | 0.553 | 0.402 | 0.053 | | 0.859 | 0.270 | 0.576 |
| Extracapsular nodal extension | Rho | 0.038 | −0.212 | −0.042 | −0.083 | 0.028 | 0.348 | 0.077 | 0.077 | −0.127 | −0.027 | | 0.224 | −0.109 | | 0.801 | 0.153 | 0.780 | 0.577 | 0.852 | 0.016 | 0.607 | 0.607 | 0.395 | 0.859 | | 0.130 | 0.465 |
| Stage | Rho | 0.182 | −0.038 | 0.349 | 0.305 | 0.091 | 0.336 | −0.119 | 0.053 | 0.090 | 0.164 | 0.224 | | −0.151 | | 0.220 | 0.799 | 0.016 | 0.037 | 0.546 | 0.021 | 0.426 | 0.723 | 0.545 | 0.270 | 0.130 | | 0.310 |
| Smoking | Rho | 0.334 | −0.019 | −0.111 | −0.234 | −0.167 | 0.109 | 0.075 | −0.217 | −0.052 | −0.084 | −0.109 | −0.151 | | | 0.020 | 0.897 | 0.459 | 0.114 | 0.267 | 0.464 | 0.618 | 0.142 | 0.730 | 0.576 | 0.465 | 0.310 | |
| ΔΔCt CD16 (log2-fold-change) | Rho | 0.192 | −0.250 | −0.179 | −0.013 | 0.053 | 0.133 | 0.119 | −0.199 | −0.255 | −0.207 | 0.077 | −0.169 | 0.322 | | 0.191 | 0.087 | 0.229 | 0.933 | 0.728 | 0.373 | 0.426 | 0.179 | 0.083 | 0.164 | 0.607 | 0.256 | 0.026 |
| ΔΔCt CD57 (log2-fold-change) | Rho | 0.469 | −0.222 | −0.206 | −0.175 | −0.105 | 0.110 | 0.103 | −0.276 | −0.271 | −0.216 | 0.000 | −0.030 | 0.475 | | 0.001 | 0.129 | 0.164 | 0.240 | 0.487 | 0.464 | 0.489 | 0.060 | 0.065 | 0.144 | 1.000 | 0.839 | 0.001 |
| ΔΔCt TGF-β1 (log2-fold-change) | Rho | 0.151 | −0.090 | −0.207 | −0.063 | 0.048 | 0.156 | 0.073 | −0.230 | −0.146 | −0.181 | 0.010 | −0.009 | 0.409 | | 0.307 | 0.543 | 0.164 | 0.674 | 0.751 | 0.294 | 0.627 | 0.120 | 0.329 | 0.224 | 0.949 | 0.954 | 0.004 |
| ΔΔCt MED15 (log2-fold-change) | Rho | 0.029 | −0.164 | −0.031 | 0.004 | 0.026 | 0.015 | 0.084 | −0.069 | −0.191 | −0.365 | −0.038 | −0.075 | 0.254 | | 0.844 | 0.266 | 0.838 | 0.979 | 0.865 | 0.923 | 0.573 | 0.645 | 0.198 | 0.012 | 0.797 | 0.614 | 0.082 |
|
|