Downregulation of Thromboxane A₂ Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery

Figure 1

(a) Contractile responses to U46619 in the fresh segments or following organ culture for 6 or 24 h. Data are shown as means ± SEM (–16). Two-way ANOVA with Bonferroni post test was used. ,   versus fresh. (b) TP receptor mRNA expression in fresh renal arterial segments or organ cultured for 24 h. Data are shown as means ± SEM (–8). Unpaired Student’s -test was used. versus fresh. Fresh = noncultured segments; OC 6 h = organ cultured for 6 h; OC 24 h = organ cultured for 24 h.

(a)

(b)