Downregulation of Thromboxane A₂ Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery

Figure 2

Effects of the transcriptional inhibitor actinomycin D (ACD 5 mg/L) on U46619-induced contraction. The artery segments were organ cultured in the presence of vehicle or ACD (5 mg/L) for 24 h. Fresh = noncultured segments. Data are shown as means ± SEM. Each data point is derived from 4–8 experiments.