|
| Cluster | Symbol | Pathways | Diseases |
|
| 1 | CASP3 | Caspase-3 | Cancer |
| CASP9 | Caspase-9 | Aging, cancer, chemdependency |
| BAX | BCL2-associated X and apoptosis regulator | Colorectal cancer, somatic, T-cell acute lymphoblastic leukemia |
| TP53 | Tumor protein p53 | Breast cancer, colorectal cancer, hepatocellular carcinoma, etc. |
| BAD | BCL2-associated agonist of cell death | Cancer, hematological, infection |
| GSK3B | Glycogen synthase kinase 3 beta | Cancer |
| POU5F1 | POU class 5 homeobox 1 | Chemdependency |
| MAPK14 | Mitogen-activated protein kinase 14 | Chemdependency |
| CREB1 | cAMP responsive element-binding protein 1 | Histiocytoma |
| SOX2 | SRY-box 2 | Optic nerve hypoplasia and abnormalities of the central nervous system |
| KLF4 | Kruppel like factor 4 | Cardiovascular and metabolic diseases |
|
| 2 | MTOR | Mechanistic target of rapamycin | Aging, cancer, chemdependency |
| PRKACA | Protein kinase cAMP-activated catalytic subunit alpha | Cushing syndrome |
| MAPK10 | Mitogen-activated protein kinase 10 | Metabolic diseases |
| STAT1 | Signal transducer and activator of transcription 1 | Mycobacterial and viral infections |
| ACTB | Actin beta | Baraitser-winter syndrome 1 and dystonia |
| BCL2L11 | BCL2 like 11 | Cancer, cardiovascular diseases |
| SIRT1 | Sirtuin 1 | Aging, cancer, cardiovascular diseases |
| TUBB3 | Tubulin beta 3 class III | Fibrosis, cortical dysplasia, brain malformations |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | Burkitt lymphoma |
|
| 3 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | Aging |
| CASP8 | Caspase-8 | Breast cancer, lung cancer |
| AKT1 | AKT serine/threonine kinase 1 | Breast cancer, somatic, colorectal cancer, ovarian cancer, schizophrenia |
| BCL2 | BCL2, apoptosis regulator | Leukemia/lymphoma |
| CYCS | Cytochrome c, somatic | Thrombocytopenia |
| MAPK11 | Mitogen-activated protein kinase 11 | Unknown |
| MAPK13 | Mitogen-activated protein kinase 13 | Unknown |
| CTNNB1 | Catenin beta 1 | Colorectal cancer, hepatocellular carcinoma, ovarian cancer and mental retardation |
|
