Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Figure 7

Desirability ramp for numerical optimization of five goals, namely, (a) PEG 6000, (b) crospovidone, (c) compression force, (d) friability, and (e) disintegration time.

(a)

(b)

(c)

(d)

(e)