The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ET<sub>A</sub> Receptor in Mouse Mesenteric Arteries

<div>3-MA inhibits the effect of mmLDL on the ET<sub>A</sub> receptor in VSMCs. (a) 3-MA antagonizes the mmLDL-strengthened contractile curves induced by ET-1 in a dose-dependent manner. (b) The mRNA expression of the ET<sub>A</sub> receptor (relative to GAPDH; <i>n</i> = 6). (c) The protein levels of the ET<sub>A</sub> receptor (<i>n</i> = 4, with each sample as a pool of 2 mesenteric arteries). Data are presented as the mean ± SEM. Statistical analyses were performed using one-way analysis of variance (ANOVA) with Dunnett’s posttest and two-way ANOVA with Bonferroni’s posttest. <svg height="10.7395pt" id="M10" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 68.3436 10.7395" width="68.3436pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 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27V0H384Z"></path></g></svg> vs. the NS (normal saline) group. <svg height="12.1645pt" id="M11" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.5275 54.2341 12.1645" width="54.2341pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.432,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.395,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 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27V0H384Z"></path></g></svg> vs. the mmLDL group.</div>

Advances in Pharmacological and Pharmaceutical Sciences

fig1

Figure 1

Figure 1: The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ET<sub>A</sub> Receptor in Mouse Mesenteric Arteries 

Advances in Pharmacological and Pharmaceutical Sciences

The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries

Figure 1

The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ET_A Receptor in Mouse Mesenteric Arteries