The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ET<sub>A</sub> Receptor in Mouse Mesenteric Arteries

<div>Western blot analysis showing that 3-MA inhibits the effect of mmLDL on the protein levels of Class III PI3K, Beclin-1, LC3 II/I, and p62. (a) The protein levels of class III PI3K. (b) The protein levels of Beclin-1. (c) The protein levels of LC3 II/I. (d) The protein levels of p62. All values are expressed as the mean ± SEM. <i>n</i> = 4, with each sample as a pool of 2 mesenteric arteries. 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NS (normal saline) group. <svg height="12.1645pt" id="M28" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.5275 54.2341 12.1645" width="54.2341pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.432,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.395,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 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group.</div>

Advances in Pharmacological and Pharmaceutical Sciences

fig2

Figure 2

Figure 2: The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ET<sub>A</sub> Receptor in Mouse Mesenteric Arteries 

Advances in Pharmacological and Pharmaceutical Sciences

The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries

Figure 2

The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ET_A Receptor in Mouse Mesenteric Arteries