Hypoglycemic Effect of a Combined Andrographis paniculata and Caesalpinia sappan Extract in Streptozocin-Induced Diabetic Rats

Figure 2

(a) Immunohistochemistry staining of pancreatic islets. (A) Section of the pancreas of the NC group showing immunoreactivity of insulin in β-cells occupying most of the islets; (B) the pancreas of the DM group showing a reduction in the immunohistochemistry expression of insulin in β-cells; (C) section from the MET group (diabetic rats + metformin) showing an apparent increase in the number and area of β-cells compared with the DM group; (D) section from the APE group (diabetic rats + APE 100 mg) showing an apparent increase in the number and area of β-cells compared with the DM group; (E) pancreas from the CSE group (diabetic rats + CSE 100 mg) showing an apparent increase in the number and area of β-cells compared with DM group; (F) section from the APCSE100 group (diabetic rats + APCSE 100 mg) showing a lower density of insulin expressing β-cells; (G) the area from the APCSE200 group (diabetic rats + APCSE 200 mg) showing an increase in insulin expressing β-cells with normal density. (b) β-Cell count of the pancreas. Results presented are mean ± SEM; significantly different from DM and significantly different from normal .

(a)

(b)