ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics

Figure 4

Activity of peptides and small molecules against ACE2 : S1 RBD binding. (a) Dose-response of the peptide candidates (Pep 1–6) against the binding of ACE2 and S1 RBD shown in blue and the respective half-maximal inhibitory concentrations. (b) Dose-response relationships of the 4 small molecules we tested for competitive inhibition of ACE2 : S1 RBD binding.

(a)

(b)