Ascorbic Acid Significantly Decreases Creatine Kinase Plasma Levels in an Animal Model of Statin/Fibrate-Induced Myopathy

Figure 1

Mean of the swimming tolerance times of rats in 3 groups. ATV, atorvastatin (80 mg/kg/day for 10 days); GMF, gemfibrozil (1000 mg/kg/day for 10 days); Vit. C, ascorbic acid (50 mg/kg/day). Swimming was done in days 8, 9, and 10. The levels of each bar are mean, and the error bar is SEM (n = 6 in each group). ^∗∗∗ value <0.001 and ^∗∗ value <0.01 in comparison with the control group. ^∗ value <0.05 in comparison with the ATV/GMF plus swim group. One-way ANOVA followed by Tukey’ post hoc test.