Ascorbic Acid Significantly Decreases Creatine Kinase Plasma Levels in an Animal Model of Statin/Fibrate-Induced Myopathy

Figure 3

Comparison between control and treated groups of rats regarding plasma lactate dehydrogenase (LDH) levels. ATV, atorvastatin (80 mg/kg/day for 10 days); GMF, gemfibrozil (1000 mg/kg/day for 10 days); Vit. C, ascorbic acid (50 mg/kg/day for 10 days). Swimming was done in days 8, 9, and 10. The levels of each bar are mean, and the error bar is SEM (n = 6 in each group). ^∗∗∗ value <0.001 in comparison with the groups which did not have swimming. LDH levels did not decrease significantly in the ATV/GMF/Vit. C plus swim group compared with the ATV/GMF plus swim group ( value >0.05). One-way ANOVA followed by Tukey’ post hoc test.