In Vitro and In Vivo Antiproliferative Actions of Solanum gilo Raddi (Solanaceae) Fruit Extract on Breast Tissues
Table 2
Effects of S. gilo hydroethanolic extract on relative wet weight of various organs after 16 weeks of treatment.
Organs
NOR
E2V
TAMOX + E2V
Solanum gilo (mg/kg) + E2V
125
250
500
Uterus
4817.1 ± 435.2
2981.9 ± 284.9##
864.6 ± 55.7
2879.2 ± 221.2
2410.7 ± 164.7
2261.1 ± 272.5
Liver
25171.2 ± 686.4
29391.3 ± 329.7#
29507.6 ± 1032.6
27970.6 ± 831.2
26873.4 ± 894.3
25253.7 ± 500.4
Lung
7887.3 ± 192.5
8294.7 ± 440.8
8938.1 ± 281.7
7734.6 ± 489.5
8265.7 ± 646.8
6161.2 ± 345.9
Spleen
2640.1 ± 83.5
3488.6 ± 162.5##
2741.9 ± 91.2
2621.8 ± 179.8
2902.9 ± 162.3
2092.8 ± 102.9
Adrenals
415.4 ± 8.2
410.1 ± 23.6
318.9 ± 13.9
342.8 ± 22.8
372.8 ± 42.9
287.2 ± 30.3
Kidneys
6474.1 ± 60.3
6276.8 ± 209.9
6808.4 ± 137.2
6001.1 ± 141.5
6026.4 ± 229.4
5629.9 ± 116.1#
Femur
2511.2 ± 63.5
2458.1 ± 38.4
2509.9 ± 38.9
2483.8 ± 91.6
2508.7 ± 73.8
2508.7 ± 73.8
Brain
9543.5 ± 363.1
10215.3 ± 265.6
11304.1 ± 93.1##
10039.5 ± 106.7
10670.6 ± 340.2
11004.7 ± 350.7#
Ovaries
801.4 ± 16.4
735.9 ± 40.6
320.2 ± 40.6
320.2 ± 13.2
524.4 ± 23.9
499.2 ± 16.1
NOR = Normal control treated with distilled water; E2V = E2V-control treated with distilled water; SG + E2V = Animals treated with the S. gilo hydroethanolic extract at the doses of 125, 250, and 500 mg/kg BW. TAM + E2V = Animals treated with tamoxifen (3.3 mg/kg BW); all groups except the normal group (NOR) received chronic administration of E2V at the dose of 1 mg/kg BW. Data are represented as mean ± SEM (n = 6). ,, and as compared to negative control; and as compared to normal control.
