In Vitro and In Vivo Antiproliferative Actions of Solanum gilo Raddi (Solanaceae) Fruit Extract on Breast Tissues
Table 3
Effects of S. gilo hydroethanolic extract on biochemical parameters after 16 weeks of treatment.
Items
NOR
E2V
TAMOX + E2V
Solanum gilo (mg/kg) + E2V
125
250
500
Transaminases
ALT
42.3 ± 2.5
45.8 ± 2.1
45.2 ± 2.2
48.7 ± 4.6
46.2 ± 2.5
39.6 ± 2.8
AST
25.3 ± 3.5
31.2 ± 2.5#
37.7 ± 2.1##
37.8 ± 4.9##
34.6 ± 2.5#
27.1 ± 3.1
Hematological
WBC (×103μL−1)
14.5 ± 0.7
12.9 ± 0.6
12.9 ± 1.1
10.1 ± 1.5#
8.3 ± 1.1##
6.1 ± 1.1###
Lymphocytes (%)
47.5 ± 1.1
57.6 ± 1.6#
46.7 ± 1.1
42.6 ± 1.1
45.5 ± 1.5
41.7 ± 1.3
Monocytes (%)
13.1 ± 0.6
13.1 ± 0.9
19.2 ± 0.9#
20.4 ± 0.7##
19.3 ± 1.7#
20.2 ± 2.3#
Granulocytes (%)
39.5 ± 0.6
29.4 ± 0.9#
34.3 ± 1.1
37.2 ± 0.7
35.2 ± 2.7
38.3 ± 1.6
RBC (×103μL−1)
8.5 ± 0.1
8.1 ± 0.1
7.8 ± 0.2
8.4 ± 0.2
8.5 ± 0.3
8.5 ± 0.2
Hematocrit (%)
44.5 ± 0.6
42.7 ± 0.7
42.9 ± 0.5
44.7 ± 0.7
43.2 ± 3.7
48.5 ± 1.5
MCV (fL)
52.3 ± 0.8
52.7 ± 0.3
54.9 ± 0.4
5.6 ± 0.9
59.6 ± 4.2
57.3 ± 0.6
Platelets (×103μL−1)
900.3 ± 32.5
802.6 ± 15.1
789.8 ± 14.5
945.6 ± 25.7
386.6 ± 116.6###
698.2 ± 63.7
MCH (pg)
16.5 ± 0.2
16.4 ± 0.2
16.9 ± 0.1
16.7 ± 0.3
17.5 ± 0.5
16.9 ± 0.2
Hemoglobin (g/dL)
140.7 ± 2.1
133.6 ± 3.1
133.3 ± 1.8
140.3 ± 2.2
139.2 ± 7.9
144.2 ± 4.5
MCHC (g/dL)
316.3 ± 0.9
312.4 ± 3.2
309.8 ± 1.3
312.4 ± 0.7
331.8 ± 18.1
296.8 ± 2.4
NOR = Normal control treated with distilled water; E2V = E2V-control treated with distilled water; SG + E2V = Animals treated with the S. gilo hydroethanolic extract at the doses of 125, 250, and 500 mg/kg BW. TAM + E2V = Animals treated with tamoxifen (3.3 mg/kg BW); all groups except the normal group (NOR) received chronic administration of E2V at the dose of 1 mg/kg BW. Data are represented as mean ± SEM (n = 6). ,, and as compared to negative control; ;, as compared to normal control.
