Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques

Figure 3

Fourier transform infrared spectroscopy spectrum of pure rosuvastatin ROS, urea, sodium benzoate, sodium salicylate, rosuvastatin physical mixture (PM) (physical combination of rosuvastatin and hydrotropic agents in a ratio of 1 : 4), rosuvastatin solid dispersion by freeze dryer (SDFD) (combination of rosuvastatin and hydrotropic agents in a ratio of 1 : 4), and rosuvastatin solid dispersion by rotary evaporator (SDRE) (combination of rosuvastatin and hydrotropic agents in a ratio of 1 : 4).