Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques

<div>Comparative DSC thermogram of pure rosuvastatin calcium (ROS), rosuvastatin physical mixture (PM) (physical combination of rosuvastatin and hydrotropic agents in a ratio of 1 : 4), rosuvastatin solid dispersions prepared using a freeze dryer (SDFD), and rosuvastatin solid dispersions prepared using a rotary evaporator (SDRE).</div>

Advances in Pharmacological and Pharmaceutical Sciences

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Figure 4

Figure 4: Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques 