Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques

Figure 6

The scanning electron microscopy image of rosuvastatin physical mixture (PM) (physical combination of rosuvastatin and hydrotropic agents in a ratio of 1 : 4) (a), rosuvastatin solid dispersion (rosuvastatin and hydrotropic agents prepared by freeze dryer (SDFD) in a ratio of 1 : 4) (b), and rosuvastatin solid dispersion (rosuvastatin and hydrotropic agents prepared by rotary evaporator (SDRE) in a ratio of 1 : 4) (c).

(a)

(b)

(c)