Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques
Table 3
Rosuvastatin calcium equilibrium solubility in various hydrotropic agents such as urea, mannitol, citric acid, sodium benzoate, and sodium salicylate in different ratios of 10%, 20%, 30%, and 40% w/v.
Hydrotropic agents
Concentration 10% W/V
Concentration 20% W/V
Concentration 30% W/V
Concentration 40% WV
Solubility enhancement ratio
Urea
0.85 ± 0.07
1.06 ± 0.08
1.13 ± 0.16
1.36 ± 0.10
3.198
Mannitol
0.49 ± 0.13
0.599 ± 0.09
0.66 ± 0.10
0.89 ± .028
2.085
Citrate acid
0.45 ± 0.003
0.75 ± 0.05
0.78 ± 0.1
0.93 ± 0.17
2.192
Sodium benzoate
22.91 ± 1.46
39.03 ± 4.53
102.66 ± 14.1
118.6 ± 13.8
277.556
Sodium salicylate
26.97 ± 1.04
49.92 ± 2.58
97.32 ± 4.13
125.19 ± 1.8
292.961
Solubility in mg/ml; U, urea; M, mannitol; C, citric acid; SB, sodium benzoate; SS, sodium salicylate. The information is presented as the mean ± SD (N = 3).
